| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Far upstream element-binding protein 2 (N-Term) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KHSRP |
| Gene ID: |
8570 |
| Uniprot ID: |
FUBP2_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
FBP2 Polyclonal Antibody detects endogenous levels of FBP2 protein. |
| Immunogen: |
Synthesized peptide derived from the N-terminal region of human FBP2. |
| Post Translational Modifications | Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function. |
| Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. |
| Protein Name | Far Upstream Element-Binding Protein 2Fuse-Binding Protein 2Kh Type-Splicing Regulatory ProteinKsrpP75 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-450604 |
| Cellular Localisation | NucleusCytoplasmA Small Proportion Is Also Found In The Cytoplasm Of Neuronal Cell Bodies And Dendrites |
| Alternative Antibody Names | Anti-Far Upstream Element-Binding Protein 2 antibodyAnti-Fuse-Binding Protein 2 antibodyAnti-Kh Type-Splicing Regulatory Protein antibodyAnti-Ksrp antibodyAnti-P75 antibodyAnti-KHSRP antibodyAnti-FUBP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
