| Function | Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening. The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens. Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. Isoform 3: Does not function as a small conductance calcium-activated potassium channel (Probable). Selectively suppresses endogenous KCNN3 currents, in a dominant-negative fashion by decreasing the abundance of functional channels in the plasma membrane, possibly by selectively coassembling with and sequestering native KCNN3 protein in intracellular compartments. This dominant inhibitory effect extends to other members of the SK subfamily. |
| Protein Name | Small Conductance Calcium-Activated Potassium Channel Protein 3Sk3Skca 3Skca3Kca2.3 |
| Database Links | Reactome: R-HSA-1296052 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 antibodyAnti-Sk3 antibodyAnti-Skca 3 antibodyAnti-Skca3 antibodyAnti-Kca2.3 antibodyAnti-KCNN3 antibodyAnti-K3 antibody |
Information sourced from Uniprot.org
