Anti-ITPR2 antibody (100-150) {Biotin} (STJ501516)

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STJ501516-100
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-ITPR2 (100-150) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Biotin
Isotype: IgG
Formulation: Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Purification: Affinity Purified
Concentration: 0.66 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Itpr2
Gene ID: 81678
Uniprot ID: ITPR2_RAT
Immunogen Region: 100-150
Immunogen: Synthetic peptide taken within amino acid region 100-150 on rat Inosital 1, 4, 5-triphosphate receptor type 2 protein.
Post Translational Modifications Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability. Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Function Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states.a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity.
Protein Name Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2
Ip3 Receptor Isoform 2
Ip3r 2
Insp3r2
Inositol 1 -4 -5-Trisphosphate Receptor Type 2
Type 2 Inositol 1 -4 -5-Trisphosphate Receptor
Type 2 Insp3 Receptor
Database Links Reactome: R-RNO-114508
Reactome: -RNO-139853
Reactome: -RNO-381676
Reactome: -RNO-5578775
Reactome: -RNO-983695
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle
Secretory Vesicle Membrane
Forms Clusters On Endoplasmic Reticulum Membrane Upon Inositol 1
4
5-Trisphosphate Binding
Alternative Antibody Names Anti-Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 antibody
Anti-Ip3 Receptor Isoform 2 antibody
Anti-Ip3r 2 antibody
Anti-Insp3r2 antibody
Anti-Inositol 1 -4 -5-Trisphosphate Receptor Type 2 antibody
Anti-Type 2 Inositol 1 -4 -5-Trisphosphate Receptor antibody
Anti-Type 2 Insp3 Receptor antibody
Anti-Itpr2 antibody

Information sourced from Uniprot.org

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