| Tissue Specificity | Expressed in many tissues. Highest levels of expression in adult heart and placenta. |
| Function | Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings. GABARs containing epsilon subunit may regulate cardiac function (Probable). |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit EpsilonGaba(A Receptor Subunit EpsilonGabaar Subunit Epsilon |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Epsilon antibodyAnti-Gaba(A Receptor Subunit Epsilon antibodyAnti-Gabaar Subunit Epsilon antibodyAnti-GABRE antibody |
Information sourced from Uniprot.org
