| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GABRE |
| Gene ID: |
2564 |
| Uniprot ID: |
GBRE_HUMAN |
| Immunogen Region: |
23-253 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-253 of human GABRE (NP_004952.2). |
| Immunogen Sequence: |
PQTESKNEASSRDVVYGPQP QPLENQLLSEETKSTETETG SRVGKLPEASRILNTILSNY DHKLRPGIGEKPTVVTVEIS VNSLGPLSILDMEYTIDIIF SQTWYDERLCYNDTFESLVL NGNVVSQLWIPDTFFRNSKR THEHEITMPNQMVRIYKDGK VLYTIRMTIDAGCSLHMLRF PMDSHSCPLSFSSFSYPENE MIYKWENFKLEINEKNSWKL FQFDFTGVSNK |
| Tissue Specificity | Expressed in many tissues. Highest levels of expression in adult heart and placenta. |
| Function | Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings. GABARs containing epsilon subunit may regulate cardiac function (Probable). |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit EpsilonGaba(A Receptor Subunit EpsilonGabaar Subunit Epsilon |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Epsilon antibodyAnti-Gaba(A Receptor Subunit Epsilon antibodyAnti-Gabaar Subunit Epsilon antibodyAnti-GABRE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
