||Human, Mouse, Rat
||Rabbit polyclonal anti-CHMP1B antibody is suitable for use in Western Blot and Immunohistochemistry.
||FOR RESEARCH USE ONLY (RUO).
||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
||Store at-20°C. Avoid freeze/thaw cycles.
||WB: 1:500-1:2000IHC: 1:50-1:100
||Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human CHMP1B (NP_065145.2).
| Tissue Specificity || Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain. |
| Function || Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release. |
| Protein Name || Charged Multivesicular Body Protein 1bChmp1.5Chromatin-Modifying Protein 1bChmp1bVacuolar Protein Sorting-Associated Protein 46-2Vps46-2Hvps46-2 |
| Cellular Localisation || CytoplasmCytosolEndosomeLate Endosome MembranePeripheral Membrane ProteinLocalizes To The Midbody Of Dividing CellsColocalizing With Cep55 And Chmp5Localized At The Periphery Of The Fleming Body |
| Alternative Antibody Names || Anti-Charged Multivesicular Body Protein 1b antibodyAnti-Chmp1.5 antibodyAnti-Chromatin-Modifying Protein 1b antibodyAnti-Chmp1b antibodyAnti-Vacuolar Protein Sorting-Associated Protein 46-2 antibodyAnti-Vps46-2 antibodyAnti-Hvps46-2 antibodyAnti-CHMP1B antibodyAnti-C18orf2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance