Anti-CD274/PD-L1/B7-H1 nanobody [SAA0904] (STJN000309)

Anti-CD274/PD-L1/B7-H1 nanobody [SAA0904] (STJN000309)

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STJN000309
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Programmed Cell Death 1 Ligand 1 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA0904
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: CD274
Gene ID: 29126
Uniprot ID: PD1L1_HUMAN
Post Translational Modifications Ubiquitinated.STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation. Ubiquitinated by MARCHF8.leading to degradation. Deubiquitinated by USP22.leading to stabilization.
Function Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Protein Name Programmed Cell Death 1 Ligand 1
Pd-L1
Pdcd1 Ligand 1
Programmed Death Ligand 1
Hpd-L1
B7 Homolog 1
B7-H1
Cd Antigen Cd274
Database Links Reactome: R-HSA-389948
Reactome: R-HSA-9701898
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Nucleus
Associates With Cmtm6 At Recycling Endosomes
Where It Is Protected From Being Targeted For Lysosomal Degradation
Translocates To The Nucleus In Response To Hypoxia Via Its Interaction With Phosphorylated Stat3
Isoform 1: Cell Membrane
Isoform 2: Endomembrane System
Isoform 4: Secreted
Alternative Nanobody Names Anti-Programmed Cell Death 1 Ligand 1 nanobody
Anti-Pd-L1 nanobody
Anti-Pdcd1 Ligand 1 nanobody
Anti-Programmed Death Ligand 1 nanobody
Anti-Hpd-L1 nanobody
Anti-B7 Homolog 1 nanobody
Anti-B7-H1 nanobody
Anti-Cd Antigen Cd274 nanobody
Anti-CD274 nanobody
Anti-B7H1 nanobody
Anti-PDCD1L1 nanobody
Anti-PDCD1LG1 nanobody
Anti-PDL1 nanobody

Information sourced from Uniprot.org

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