| Host: |
Rabbit |
| Applications: |
WB, IF, ICC, ELISA |
| Reactivity: |
Human, Mouse |
| Note: |
FOR RESEARCH USE ONLY (RUO). |
| Short Description: |
Rabbit polyclonal antibody anti-Atypical Chemokine Receptor 4 (260-340 C-Term) is suitable for use in Western Blot, Immunofluorescence, Immunocytochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACKR4 |
| Gene ID: |
51554 |
| Uniprot ID: |
ACKR4_HUMAN |
| Immunogen Region: |
260-340 C-Term |
| Specificity: |
ACKR4 polyclonal antibody (Atypical Chemokine Receptor 4) binds to endogenous Atypical Chemokine Receptor 4 at the amino acid region 260-340 C-Term. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human CCRL1 at amino acid range 291-340 |
| Post Translational Modifications | The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated. |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. |
| Protein Name | Atypical Chemokine Receptor 4C-C Chemokine Receptor Type 11C-C Ckr-11Cc-Ckr-11Ccr-11Cc Chemokine Receptor-Like 1Ccrl1Ccx Ckr |
| Database Links | Reactome: R-HSA-380108 |
| Cellular Localisation | Early EndosomeRecycling EndosomeCell MembraneMulti-Pass Membrane ProteinPredominantly Localizes To Endocytic VesiclesAnd Upon Stimulation By The Ligand Is Internalized Via CaveolaeOnce InternalizedThe Ligand Dissociates From The ReceptorAnd Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane |
| Alternative Antibody Names | Anti-Atypical Chemokine Receptor 4 antibodyAnti-C-C Chemokine Receptor Type 11 antibodyAnti-C-C Ckr-11 antibodyAnti-Cc-Ckr-11 antibodyAnti-Ccr-11 antibodyAnti-Cc Chemokine Receptor-Like 1 antibodyAnti-Ccrl1 antibodyAnti-Ccx Ckr antibodyAnti-ACKR4 antibodyAnti-CCBP2 antibodyAnti-CCR11 antibodyAnti-CCRL1 antibodyAnti-VSHK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
