Anti-ABCD2 antibody (310-390) (STJ190582)

SKU:
STJ190582

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Rat, Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family D Member 2 (310-390) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCD2
Gene ID: 225
Uniprot ID: ABCD2_HUMAN
Immunogen Region: 310-390
Specificity: ABCD2 polyclonal antibody (Atp-Binding Cassette Sub-Family D Member 2) binds to endogenous Atp-Binding Cassette Sub-Family D Member 2 at the amino acid region 310-390.
Immunogen: Synthesized peptide derived from human protein at aa range 310-390
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation.
Protein Name Atp-Binding Cassette Sub-Family D Member 2
Adrenoleukodystrophy-Like 1
Adrenoleukodystrophy-Related Protein
Haldr
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-9603798
Cellular Localisation Peroxisome Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family D Member 2 antibody
Anti-Adrenoleukodystrophy-Like 1 antibody
Anti-Adrenoleukodystrophy-Related Protein antibody
Anti-Haldr antibody
Anti-ABCD2 antibody
Anti-ALD1 antibody
Anti-ALDL1 antibody
Anti-ALDR antibody
Anti-ALDRP antibody

Information sourced from Uniprot.org

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