Anti-ABCC11 antibody (50-130) (STJ190587)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Rat, Mouse
Short Description: Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family C Member 11 (50-130) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCC11
Gene ID: 85320
Uniprot ID: MRP8_HUMAN
Immunogen Region: 50-130
Specificity: ABCC11 polyclonal antibody (Atp-Binding Cassette Sub-Family C Member 11) binds to endogenous Atp-Binding Cassette Sub-Family C Member 11 at the amino acid region 50-130.
Immunogen: Synthesized peptide derived from human protein at aa range 50-130
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Enhances also the cellular extrusion of cAMP and cGMP. Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate. Probably functions to secrete earwax. Required for the secretion of components contributing to axillary odor formation.
Protein Name Atp-Binding Cassette Sub-Family C Member 11
Multidrug Resistance-Associated Protein 8
Database Links Reactome: R-HSA-382556
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Vacuole Membrane
Cytoplasmic Vesicle Membrane
Apical Cell Membrane
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 11 antibody
Anti-Multidrug Resistance-Associated Protein 8 antibody
Anti-ABCC11 antibody
Anti-MRP8 antibody

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