| Host: |
Rabbit |
| Applications: |
WB, ELISA |
| Reactivity: |
Human, Rat, Mouse |
| Note: |
FOR RESEARCH USE ONLY (RUO). |
| Short Description: |
Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family C Member 11 (50-130) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS, 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCC11 |
| Gene ID: |
85320 |
| Uniprot ID: |
MRP8_HUMAN |
| Immunogen Region: |
50-130 |
| Specificity: |
ABCC11 polyclonal antibody (Atp-Binding Cassette Sub-Family C Member 11) binds to endogenous Atp-Binding Cassette Sub-Family C Member 11 at the amino acid region 50-130. |
| Immunogen: |
Synthesized peptide derived from human protein at aa range 50-130 |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Enhances also the cellular extrusion of cAMP and cGMP. Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate. Probably functions to secrete earwax. Required for the secretion of components contributing to axillary odor formation. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 11Multidrug Resistance-Associated Protein 8 |
| Database Links | Reactome: R-HSA-382556 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinVacuole MembraneCytoplasmic Vesicle MembraneApical Cell Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 11 antibodyAnti-Multidrug Resistance-Associated Protein 8 antibodyAnti-ABCC11 antibodyAnti-MRP8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
