Anti-ABCA4 antibody (630-710aa) (STJ191313)

SKU:
STJ191313

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody Anti-Retinal-specific phospholipid-transporting ATPase (630-710aa) is suitable for use in Western Blot and ELISA.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Purification: ABCA4 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Concentration: 1 mg/ml
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCA4
Gene ID: 24
Uniprot ID: ABCA4_HUMAN
Immunogen Region: 630-710aa
Specificity: ABCA4 polyclonal antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from human ABCA4 protein.
Function Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylethanolamine. In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
Protein Name Retinal-Specific Phospholipid-Transporting Atpase Abca4
Atp-Binding Cassette Sub-Family A Member 4
Rim Abc Transporter
Rim Protein
Rmp
Retinal-Specific Atp-Binding Cassette Transporter
Stargardt Disease Protein
Database Links Reactome: R-HSA-2453864
Reactome: R-HSA-2453902
Reactome: R-HSA-382556
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum
Localized To Outer Segment Disk Edges Of Rods And Cones
With Around One Million Copies/Photoreceptor
Alternative Antibody Names Anti-Retinal-Specific Phospholipid-Transporting Atpase Abca4 antibody
Anti-Atp-Binding Cassette Sub-Family A Member 4 antibody
Anti-Rim Abc Transporter antibody
Anti-Rim Protein antibody
Anti-Rmp antibody
Anti-Retinal-Specific Atp-Binding Cassette Transporter antibody
Anti-Stargardt Disease Protein antibody
Anti-ABCA4 antibody
Anti-ABCR antibody

Information sourced from Uniprot.org

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