5HT2C Receptor protein (STJ505511)


Current Stock:
Applications: WB
Short Description: 5HT2C Receptor-protein if for use in research applications.
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: HTR2C
Gene ID: 3358
Uniprot ID: 5HT2C_HUMAN
Tissue Specificity Detected in brain.
Post Translational Modifications N-glycosylated.
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Protein Name 5-Hydroxytryptamine Receptor 2c
5-Hydroxytryptamine Receptor 1c
Serotonin Receptor 2c
Database Links Reactome: R-HSA-390666
Reactome: R-HSA-416476
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-5-Hydroxytryptamine Receptor 2c antibody
Anti-5-Ht-2c antibody
Anti-5-Ht2c antibody
Anti-5-Htr2c antibody
Anti-5-Hydroxytryptamine Receptor 1c antibody
Anti-5-Ht-1c antibody
Anti-5-Ht1c antibody
Anti-Serotonin Receptor 2c antibody
Anti-HTR2C antibody
Anti-HTR1C antibody

Information sourced from Uniprot.org

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