14-3-3 sigma protein (STJ505622)


Current Stock:
Applications: Immunodepletion, Immunocompetition
Short Description: 14-3-3 sigma-protein if for use in research applications.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SFN
Gene ID: 2810
Uniprot ID: 1433S_HUMAN
Immunogen Region: 150-220
Immunogen: Synthetic peptide taken within amino acid region 150-220 on human 14-3-3 protein sigma/STRATIFIN/SFN protein.
Tissue Specificity Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Post Translational Modifications Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. p53-regulated inhibitor of G2/M progression.
Protein Name 14-3-3 Protein Sigma
Epithelial Cell Marker Protein 1
Database Links Reactome: R-HSA-111447
Reactome: R-HSA-1445148
Reactome: R-HSA-5625740
Reactome: R-HSA-5628897
Reactome: R-HSA-6804114
Reactome: R-HSA-75035
Reactome: R-HSA-9614399
Cellular Localisation Cytoplasm
May Be Secreted By A Non-Classical Secretory Pathway
Alternative Antibody Names Anti-14-3-3 Protein Sigma antibody
Anti-Epithelial Cell Marker Protein 1 antibody
Anti-Stratifin antibody
Anti-SFN antibody
Anti-HME1 antibody

Information sourced from Uniprot.org

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