||FOR RESEARCH USE ONLY (RUO).
||14-3-3 sigma-protein if for use in research applications.
||Store at-20°C for long term storage. Avoid freeze-thaw cycles.
||Synthetic peptide taken within amino acid region 150-220 on human 14-3-3 protein sigma/STRATIFIN/SFN protein.
| Tissue Specificity || Present mainly in tissues enriched in stratified squamous keratinizing epithelium. |
| Post Translational Modifications || Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. |
| Function || Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. p53-regulated inhibitor of G2/M progression. |
| Protein Name || 14-3-3 Protein SigmaEpithelial Cell Marker Protein 1Stratifin |
| Database Links || Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-6804114Reactome: R-HSA-75035Reactome: R-HSA-9614399 |
| Cellular Localisation || CytoplasmNucleusSecretedMay Be Secreted By A Non-Classical Secretory Pathway |
| Alternative Antibody Names || Anti-14-3-3 Protein Sigma antibodyAnti-Epithelial Cell Marker Protein 1 antibodyAnti-Stratifin antibodyAnti-SFN antibodyAnti-HME1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance