||This Mouse PRF1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
||FOR RESEARCH USE ONLY (RUO).
||Store at 4°C for 6 months.
||Serum, Plasma, Biological Fluids
| Function || Pore-forming protein that plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. |
| Protein Name || Perforin-1P1CytolysinLymphocyte Pore-Forming ProteinPfp |
| Cellular Localisation || Cytoplasmic Granule LumenSecretedCell MembraneMulti-Pass Membrane ProteinEndosome LumenStored In Cytoplasmic Granules Of Cytolytic T-Lymphocytes And Secreted Into The Cleft Between T-Lymphocyte And Target CellInserts Into The Cell Membrane Of Target Cells And Forms PoresMembrane Insertion And Pore Formation Requires A Major Conformation ChangeMay Be Taken Up Via Endocytosis Involving Clathrin-Coated Vesicles And Accumulate In A First Time In Large Early Endosomes |
| Alternative ELISA Kit Names || Perforin-1 ELISA kitP1 ELISA kitCytolysin ELISA kitLymphocyte Pore-Forming Protein ELISA kitPfp ELISA kitPRF1 ELISA kitPFP ELISA kit |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance