Human YOD1 protein (Recombinant) (His-Tag) (STJP018126)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human YOD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | YOD1 |
| Gene ID | 55432 |
| Uniprot ID | OTU1_HUMAN |
| Accession Number | NP_061036.3 |
| Immunogen | Human |
| Immunogen Region | 1-348aa |
| Immunogen Sequence |
Additional Info
| Function | Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation. |
| Protein Name | Ubiquitin Thioesterase Otu1Duba-8Hiv-1-Induced Protease 7Hin-7Hshin7Otu Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Protein Names | Ubiquitin Thioesterase Otu1 proteinDuba-8 proteinHiv-1-Induced Protease 7 proteinHin-7 proteinHshin7 proteinOtu Domain-Containing Protein 2 proteinYOD1 proteinDUBA8 proteinHIN7 proteinOTUD2 proteinPRO0907 protein |
Information sourced from Uniprot.org