Human TRIM63 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007374)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRIM63-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRIM63 |
| Gene ID | 84676 |
| Uniprot ID | TRI63_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly11-Arg112 |
Additional Info
| Function | E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim63Iris Ring Finger ProteinMuscle-Specific Ring Finger Protein 1Murf-1Murf1Ring Finger Protein 28Ring-Type E3 Ubiquitin Transferase Trim63Striated Muscle Ring Zinc Finger ProteinTripartite Motif-Containing Protein 63 |
| Database Links | Reactome: R-HSA-9615017Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusMyofibrilSarcomereM LineZ LineColocalizes With Tnni3 In MyocytesLocalizes To The M- And Z-Lines In Skeletal Muscle |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim63 proteinIris Ring Finger Protein proteinMuscle-Specific Ring Finger Protein 1 proteinMurf-1 proteinMurf1 proteinRing Finger Protein 28 proteinRing-Type E3 Ubiquitin Transferase Trim63 proteinStriated Muscle Ring Zinc Finger Protein proteinTripartite Motif-Containing Protein 63 proteinTRIM63 proteinIRF proteinMURF1 proteinRNF28 proteinSMRZ protein |
Information sourced from Uniprot.org