| Function | E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim38Ring Finger Protein 15Tripartite Motif-Containing Protein 38Zinc Finger Protein Roret |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim38 proteinRing Finger Protein 15 proteinTripartite Motif-Containing Protein 38 proteinZinc Finger Protein Roret proteinTRIM38 proteinRNF15 proteinRORET protein |
Information sourced from Uniprot.org
