Human TRIM29 protein (Recombinant) (N-His-SUMO) (STJP007760)

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STJP007760
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TRIM29-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TRIM29
Gene ID: 23650
Uniprot ID: TRI29_HUMAN
Immunogen Region: Gln181-Ser256
Immunogen: Homo sapiens (Human)
Post Translational Modifications Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
Function Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Protein Name Tripartite Motif-Containing Protein 29
Ataxia Telangiectasia Group D-Associated Protein
Database Links Reactome: R-HSA-877300
Cellular Localisation Cytoplasm
Lysosome
Colocalizes With Intermediate Filaments
Alternative Protein Names Tripartite Motif-Containing Protein 29 protein
Ataxia Telangiectasia Group D-Associated Protein protein
TRIM29 protein
ATDC protein

Information sourced from Uniprot.org

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