Human TNFRSF5/CD40 protein (Recombinant) (C-hFc&His) (STJP001233)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human TNFRSF5/CD40 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu21-Arg193) of human CD40/TNFRSF5 (Accession #NP_001241.1) fused with a Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human TNFRSF5/CD40-C-hFc&His protein was developed in hek293 cells using the region Glu21-Arg193. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CD40 Ligand at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human CD40 with a linear range of 224-898 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CD40 |
| Gene ID | 958 |
| Uniprot ID | TNR5_HUMAN |
| Immunogen | Recombinant Human TNFRSF5/CD40 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu21-Arg193) of human CD40/TNFRSF5 (Accession #NP_001241.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Glu21-Arg193 |
| Immunogen Sequence | EPPTACREKQYLINSQCCSL CQPGQKLVSDCTEFTETECL PCGESEFLDTWNRETHCHQH KYCDPNLGLRVQQKGTSETD TICTCEEGWHCTSEACESCV LHRSCSPGFGVKQIATGVSD TICEPCPVGFFSNVSSAFEK CHPWTSCETKDLVVQQAGTN KTDVVCGPQDRLR |
Additional Info
| Function | Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 5B-Cell Surface Antigen Cd40Bp50Cd40l ReceptorCdw40Cd Antigen Cd40 |
| Database Links | Reactome: R-HSA-198933 P25942-1Reactome: R-HSA-5668541 P25942-1Reactome: R-HSA-5676594 P25942-1 |
| Cellular Localisation | Isoform I: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Ii: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 5 proteinB-Cell Surface Antigen Cd40 proteinBp50 proteinCd40l Receptor proteinCdw40 proteinCd Antigen Cd40 proteinCD40 proteinTNFRSF5 protein |
Information sourced from Uniprot.org