Human TGF-alpha protein (Recombinant) (No-Tag) (STJP002972)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenRecombinant Human TGF-alpha Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val40-Ala89) of human TGF-alpha/TGFA (Accession #NP_003227.1) fused with and a with no additional amino acid.
General Information
| Short Description | Recombinant-Human TGF-alpha-No-Tag protein was developed in e.coli using the region Val40-Ala89. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of 50mM Tris, 100mM NaCl, pH 8.0 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <1 EU/Mu g |
Target Information
| Gene Symbol | TGFA |
| Gene ID | 7039 |
| Uniprot ID | TGFA_HUMAN |
| Immunogen | Recombinant Human TGF-alpha Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val40-Ala89) of human TGF-alpha/TGFA (Accession #NP_003227.1) fused with and a with no additional amino acid. |
| Immunogen Region | Val40-Ala89 |
| Immunogen Sequence | PMFIVNTNVPRASVPEGFLS ELTQQLAQATGKPAQYIAVH VVPDQLMTFSGTNDPCALCS LHSIGKIGGAQNRNYSKLLC GLLSDRLHISPDRVYINYYD MNAANVGWNGSTFA |
Additional Info
| Tissue Specificity | Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. |
| Function | TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
| Protein Name | Protransforming Growth Factor Alpha Cleaved Into - Transforming Growth Factor AlphaTgf-AlphaEgf-Like TgfEtgfTgf Type 1 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-177929Reactome: R-HSA-179812Reactome: R-HSA-180292Reactome: R-HSA-180336Reactome: R-HSA-182971Reactome: R-HSA-204005Reactome: R-HSA-212718Reactome: R-HSA-2219530Reactome: R-HSA-5638303Reactome: R-HSA-5673001Reactome: R-HSA-5694530Reactome: R-HSA-6811558Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8866910Reactome: R-HSA-9009391Reactome: R-HSA-9018519Reactome: R-HSA-9634638 |
| Cellular Localisation | Transforming Growth Factor Alpha: SecretedExtracellular SpaceProtransforming Growth Factor Alpha: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Protransforming Growth Factor Alpha Cleaved Into - Transforming Growth Factor Alpha proteinTgf-Alpha proteinEgf-Like Tgf proteinEtgf proteinTgf Type 1 proteinTGFA protein |
Information sourced from Uniprot.org