Tissue Specificity | Brain and also in atria, but at much lower levels than ANP. |
Post Translational Modifications | The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro). |
Function | Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. |
Cellular Localisation | Secreted |
Protein Name | Natriuretic Peptides BGamma-Brain Natriuretic Peptide Cleaved Into - Brain Natriuretic Peptide 32Bnp(1-32Bnp-32 - Bnp(1-30 - Bnp(1-29 - Bnp(1-28 - Bnp(2-31 - Bnp(3-32 - Bnp(3-30 - Bnp(3-29 - Bnp(4-32 - Bnp(4-31 - Bnp(4-30 - Bnp(4-29 - Bnp(4-27 - Bnp(5-32 - Bnp(5-31 - Bnp(5-29 |
Alternative Names | Anti-Natriuretic Peptides B antibodyAnti-Gamma-Brain Natriuretic Peptide Cleaved Into - Brain Natriuretic Peptide 32 antibodyAnti-Bnp(1-32 antibodyAnti-Bnp-32 - Bnp(1-30 - Bnp(1-29 - Bnp(1-28 - Bnp(2-31 - Bnp(3-32 - Bnp(3-30 - Bnp(3-29 - Bnp(4-32 - Bnp(4-31 - Bnp(4-30 - Bnp(4-29 - Bnp(4-27 - Bnp(5-32 - Bnp(5-31 - Bnp(5-29 antibodyAnti-NPPB antibody |
Information sourced from Uniprot.org