| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SLC6A3-N-His-KSI protein was developed from e. coli and has a target region of N-His-KSI. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SLC6A3 |
| Gene ID: | 6531 |
| Uniprot ID: | SC6A3_HUMAN |
| Immunogen Region: | [His165-Pro235] & [Thr286-Ser309] & [Gln373-Ala399] & [Leu474-His477] & [Thr542-Ala557] |
| Immunogen: | Homo sapiens (Human) |
| Function | Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling. |
| Protein Name | Sodium-Dependent Dopamine TransporterDa TransporterDatSolute Carrier Family 6 Member 3 |
| Database Links | Reactome: R-HSA-379401Reactome: R-HSA-442660Reactome: R-HSA-5619081Reactome: R-HSA-5660724 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neurite Tips In Neuronal CellsColocalizes With Septin4 At Axon TerminalsEspecially At The Varicosities |
| Alternative Protein Names | Sodium-Dependent Dopamine Transporter proteinDa Transporter proteinDat proteinSolute Carrier Family 6 Member 3 proteinSLC6A3 proteinDAT1 protein |
Information sourced from Uniprot.org