Human SH2D1A protein (Recombinant) (N-GST & C-His) (STJP010716)

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STJP010716
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SH2D1A-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SH2D1A
Gene ID: 4068
Uniprot ID: SH21A_HUMAN
Immunogen Region: Asp2-Pro97
Immunogen: Homo sapiens (Human)
Function Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Protein Name Sh2 Domain-Containing Protein 1a
Duncan Disease Sh2-Protein
Signaling Lymphocytic Activation Molecule-Associated Protein
Slam-Associated Protein
T-Cell Signal Transduction Molecule Sap
Database Links Reactome: R-HSA-198933
Cellular Localisation Cytoplasm
Alternative Protein Names Sh2 Domain-Containing Protein 1a protein
Duncan Disease Sh2-Protein protein
Signaling Lymphocytic Activation Molecule-Associated Protein protein
Slam-Associated Protein protein
T-Cell Signal Transduction Molecule Sap protein
SH2D1A protein
DSHP protein
SAP protein

Information sourced from Uniprot.org

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