Human RANTES-CCL5 protein (Recombinant) {Biotin} (STJP000200)


Current Stock:
Host: E.coli
Applications: ELISA, WB
Short Description: Recombinant-Human RANTES-CCL5-protein was developed from e.coli. For use in research applications.
Conjugation: Biotin
Formulation: Recombinant Rantes/CCL5was lyophilized from a.2 Mu m filtered PBS solution.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: The lyophilized protein is stable for at least years from date of receipt at-20°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8°C for one month, or at-20°C for six months, with a carrier protein without detectable loss
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CCL5
Gene ID: 6352
Uniprot ID: CCL5_HUMAN
Immunogen Region: Mature chain
Tissue Specificity Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
Post Translational Modifications N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
Function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Protein Name C-C Motif Chemokine 5
Eosinophil Chemotactic Cytokine
Small-Inducible Cytokine A5
T Cell-Specific Protein P228
T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Secreted
Alternative Antibody Names Anti-C-C Motif Chemokine 5 antibody
Anti-Eocp antibody
Anti-Eosinophil Chemotactic Cytokine antibody
Anti-Sis-Delta antibody
Anti-Small-Inducible Cytokine A5 antibody
Anti-T Cell-Specific Protein P228 antibody
Anti-Tcp228 antibody
Anti-T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68 antibody
Anti-CCL5 antibody
Anti-D17S136E antibody
Anti-SCYA5 antibody

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