||FOR RESEARCH USE ONLY (RUO).
||Recombinant-Human MIP-3 beta (CCL19)-protein was developed from e.coli. For use in research applications.
||Recombinant CCL19 was lyophilized from a.2 Mu m filteredmM PB, 100mM NaCl solution pH.5.
||Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
||The lyophilized protein is stable for at least years from date of receipt at-20°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8°C for one month, or at-20°C for six months, with a carrier protein without detectable loss
||Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
||MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM DYYETNSQCS KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN
| Tissue Specificity || Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach. |
| Function || May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name || C-C Motif Chemokine 19Beta-Chemokine Exodus-3Ck Beta-11Epstein-Barr Virus-Induced Molecule 1 Ligand ChemokineEbi1 Ligand ChemokineElcMacrophage Inflammatory Protein 3 BetaMip-3-BetaSmall-Inducible Cytokine A19 |
| Database Links || Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation || Secreted |
| Alternative Antibody Names || Anti-C-C Motif Chemokine 19 antibodyAnti-Beta-Chemokine Exodus-3 antibodyAnti-Ck Beta-11 antibodyAnti-Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine antibodyAnti-Ebi1 Ligand Chemokine antibodyAnti-Elc antibodyAnti-Macrophage Inflammatory Protein 3 Beta antibodyAnti-Mip-3-Beta antibodyAnti-Small-Inducible Cytokine A19 antibodyAnti-CCL19 antibodyAnti-ELC antibodyAnti-MIP3B antibodyAnti-SCYA19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance