Human HCC-1 (CCL14) protein (Recombinant) {Biotin} (STJP000212)

SKU:
STJP000212

Current Stock:
Host: E.coli
Applications: ELISA, WB
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Recombinant-Human HCC-1 (CCL14)-protein was developed from e.coli. For use in research applications.
Conjugation: Biotin
Formulation: Recombinant HCC-1 was lyophilized from a.2 Mu m filteredmM PB, 100mM NaCl solution pH.5.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: The lyophilized protein is stable for at least years from date of receipt at-20°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8°C for one month, or at-20°C for six months, with a carrier protein without detectable loss
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CCL14
Gene ID: 6358
Uniprot ID: CCL14_HUMAN
Immunogen Region: Mature chain
Immunogen Sequence: MKVSAAALAV ILIATALCAP ASASPYSSDT TPCCFAYIAR PLPRAHIKEY FYTSGKCSNP AVVFVTRKNR QVCANPEKKW VREYINSLEM S
Tissue Specificity Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
Post Translational Modifications The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated.the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
Function Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Protein Name C-C Motif Chemokine 14
Chemokine Cc-1/Cc-3
Hcc-1/Hcc-3
Hcc-1(1-74
Ncc-2
Small-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74
Cellular Localisation Secreted
Alternative Antibody Names Anti-C-C Motif Chemokine 14 antibody
Anti-Chemokine Cc-1/Cc-3 antibody
Anti-Hcc-1/Hcc-3 antibody
Anti-Hcc-1(1-74 antibody
Anti-Ncc-2 antibody
Anti-Small-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74 antibody
Anti-CCL14 antibody
Anti-NCC2 antibody
Anti-SCYA14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance