Human GSAP protein (Recombinant) (N-His) (STJP003113)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GSAP-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GSAP |
| Gene ID | 54103 |
| Uniprot ID | GSAP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp616-Leu854 |
Additional Info
| Post Translational Modifications | The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form. |
| Function | Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. |
| Protein Name | Gamma-Secretase-Activating ProteinGsapProtein Pigeon Homolog Cleaved Into - Gamma-Secretase-Activating Protein 16 Kda C-Terminal FormGsap-16k |
| Database Links | |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network |
| Alternative Protein Names | Gamma-Secretase-Activating Protein proteinGsap proteinProtein Pigeon Homolog Cleaved Into - Gamma-Secretase-Activating Protein 16 Kda C-Terminal Form proteinGsap-16k proteinGSAP proteinPION protein |
Information sourced from Uniprot.org