Human BMP-14/GDF-5 protein (Recombinant) (His-Tag) (STJP016479)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human BMP-14/GDF-5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 10mM Sodium Citrate buffer (pH 3.5) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | GDF5 |
| Gene ID | 8200 |
| Uniprot ID | GDF5_HUMAN |
| Accession Number | NP_000548 |
| Immunogen | Human |
| Immunogen Region | 382-501aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level). |
| Function | Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. |
| Protein Name | Growth/Differentiation Factor 5Gdf-5Bone Morphogenetic Protein 14Bmp-14Cartilage-Derived Morphogenetic Protein 1Cdmp-1Lipopolysaccharide-Associated Protein 4Lap-4Lps-Associated Protein 4Radotermin |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedCell Membrane |
| Alternative Protein Names | Growth/Differentiation Factor 5 proteinGdf-5 proteinBone Morphogenetic Protein 14 proteinBmp-14 proteinCartilage-Derived Morphogenetic Protein 1 proteinCdmp-1 proteinLipopolysaccharide-Associated Protein 4 proteinLap-4 proteinLps-Associated Protein 4 proteinRadotermin proteinGDF5 proteinBMP14 proteinCDMP1 protein |
Information sourced from Uniprot.org