Goat Anti-Human IgA antibody {HRP} (STJ16101209)

SKU:
STJ16101209

Current Stock:
Host: Goat
Applications: WB, ELISA, IHC
Reactivity: Human
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: HRP-conjugated goat polyclonal anti-Human IgA secondary antibody. For use in most research applications.
Clonality: Polyclonal
Conjugation: HRP
Formulation: 0.05 M Sodium Phosphate, 0.1 M NaCl, 50% Glycerol, 5 mg/ml BSA
Concentration: 1.2 mg/ml 
Dilution Range: WB
ELISA 1:1000
IHC
Storage Instruction: Store at 2-8°C for up to 1-year, upon receipt.
Gene Symbol: CD79A
Gene ID: 973
Uniprot ID: CD79A_HUMAN
Immunogen: IgA
Post Translational Modifications Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation. Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation.
Function Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Protein Name B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain
Ig-Alpha
Mb-1 Membrane Glycoprotein
Membrane-Bound Immunoglobulin-Associated Protein
Surface Igm-Associated Protein
Cd Antigen Cd79a
Database Links Reactome: R-HSA-5690714
Reactome: R-HSA-983695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Following Antigen Binding
The Bcr Has Been Shown To Translocate From Detergent-Soluble Regions Of The Cell Membrane To Lipid Rafts Although Signal Transduction Through The Complex Can Also Occur Outside Lipid Rafts
Alternative Antibody Names Anti-B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain antibody
Anti-Ig-Alpha antibody
Anti-Mb-1 Membrane Glycoprotein antibody
Anti-Membrane-Bound Immunoglobulin-Associated Protein antibody
Anti-Surface Igm-Associated Protein antibody
Anti-Cd Antigen Cd79a antibody
Anti-CD79A antibody
Anti-IGA antibody
Anti-MB1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance