| Tissue Specificity | Widely expressed. Isoform 3 is not expressed in the pituitary gland. |
| Post Translational Modifications | Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 in vitro. Glycosylated.contains N-acetylglucosamine, probably O-linked. Ubiquitinated.regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1. Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260. Palmitoylated (isoform 3). Not biotinylated (isoform 3). Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor. |
| Database Links | Reactome: R-HSA-1251985 |
| Cellular Localisation | Isoform 1: NucleusCytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideA Minor Fraction Is Associated With The Inner MembraneIsoform 3: NucleusSingle-Pass Type I Membrane ProteinAssociated With The Inner Membrane Via Palmitoylation (Probable)At Least A Subset Exists As A Transmembrane Protein With A N-Terminal Extracellular DomainNucleusGolgi ApparatusColocalizes With Zdhhc7 And Zdhhc21 In The Golgi Apparatus Where Most Probably Palmitoylation OccursAssociated With The Plasma Membrane When Palmitoylated |
| Protein Name | Estrogen ReceptorErEr-AlphaEstradiol ReceptorNuclear Receptor Subfamily 3 Group A Member 1 |
| Alternative Names | Anti-Estrogen Receptor antibodyAnti-Er antibodyAnti-Er-Alpha antibodyAnti-Estradiol Receptor antibodyAnti-Nuclear Receptor Subfamily 3 Group A Member 1 antibodyAnti-ESR1 antibodyAnti-ESR antibodyAnti-NR3A1 antibody |
Information sourced from Uniprot.org
