• Absorbance analysis at 450nm using ESR1 ELISA Kit.

ESR1 Competitive ELISA Kit (STJ150093)

Current Stock:
Applications: ELISA
Reactivity: ESR1
Storage Instruction: Store at 4°C for 6 months.
Uniprot ID: ESR1_HUMAN
Gene ID: 2099
Gene Symbol: ESR1
Tissue Specificity Widely expressed. Isoform 3 is not expressed in the pituitary gland.
Post Translational Modifications Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 in vitro. Glycosylated.contains N-acetylglucosamine, probably O-linked. Ubiquitinated.regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1. Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260. Palmitoylated (isoform 3). Not biotinylated (isoform 3). Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor.
Database Links Reactome: R-HSA-1251985
Cellular Localisation Isoform 1: Nucleus
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
A Minor Fraction Is Associated With The Inner Membrane
Isoform 3: Nucleus
Single-Pass Type I Membrane Protein
Associated With The Inner Membrane Via Palmitoylation (Probable)
At Least A Subset Exists As A Transmembrane Protein With A N-Terminal Extracellular Domain
Golgi Apparatus
Colocalizes With Zdhhc7 And Zdhhc21 In The Golgi Apparatus Where Most Probably Palmitoylation Occurs
Associated With The Plasma Membrane When Palmitoylated
Protein Name Estrogen Receptor
Estradiol Receptor
Nuclear Receptor Subfamily 3 Group A Member 1
Alternative Names Anti-Estrogen Receptor antibody
Anti-Er antibody
Anti-Er-Alpha antibody
Anti-Estradiol Receptor antibody
Anti-Nuclear Receptor Subfamily 3 Group A Member 1 antibody
Anti-ESR1 antibody
Anti-ESR antibody
Anti-NR3A1 antibody

Information sourced from Uniprot.org

6 months standard