• Absorbance analysis at 450nm using AR ELISA Kit.

AR Competitive ELISA Kit (STJ150094)

SKU:
STJ150094
Current Stock:
Applications: ELISA
Reactivity: Human
Short Description: This AR ELISA kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Note: FOR RESEARCH USE ONLY (RUO).
Storage Instruction: Store at 4°C for 6 months.
Uniprot ID: ANDR_HUMAN
Gene ID: 367
Gene Symbol: AR
Tissue Specificity Isoform 2 is mainly expressed in heart and skeletal muscle. Isoform 3 is expressed by basal and stromal cells of prostate (at protein level).
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.
Database Links Reactome: R-HSA-3371497
Cellular Localisation Nucleus
Cytoplasm
Detected At The Promoter Of Target Genes
Predominantly Cytoplasmic In Unligated Form But Translocates To The Nucleus Upon Ligand-Binding
Can Also Translocate To The Nucleus In Unligated Form In The Presence Of Rack1
Protein Name Androgen Receptor
Dihydrotestosterone Receptor
Nuclear Receptor Subfamily 3 Group C Member 4
Alternative Names Anti-Androgen Receptor antibody
Anti-Dihydrotestosterone Receptor antibody
Anti-Nuclear Receptor Subfamily 3 Group C Member 4 antibody
Anti-AR antibody
Anti-DHTR antibody
Anti-NR3C4 antibody
6 months standard