| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZMPSTE24 (200-300) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZMPSTE24 |
| Gene ID: |
10269 |
| Uniprot ID: |
FACE1_HUMAN |
| Immunogen Region: |
200-300 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ZMPSTE24 (NP_005848.2). |
| Immunogen Sequence: |
AWLFTLVVSLVLVTIYADYI APLFDKFTPLPEGKLKEEIE VMAKSIDFPLTKVYVVEGSK RSSHSNAYFYGFFKNKRIVL FDTLLEEYSVLNKDIQEDSG M |
| Tissue Specificity | Widely expressed. High levels in kidney, prostate, testis and ovary. |
| Function | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum. Proteolytically removes the C-terminal three residues of farnesylated proteins. Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia. Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity. |
| Protein Name | Caax Prenyl Protease 1 HomologFarnesylated Proteins-Converting Enzyme 1Face-1Prenyl Protein-Specific Endoprotease 1Zinc Metalloproteinase Ste24 Homolog |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneEarly Endosome MembraneLate Endosome Membrane |
| Alternative Antibody Names | Anti-Caax Prenyl Protease 1 Homolog antibodyAnti-Farnesylated Proteins-Converting Enzyme 1 antibodyAnti-Face-1 antibodyAnti-Prenyl Protein-Specific Endoprotease 1 antibodyAnti-Zinc Metalloproteinase Ste24 Homolog antibodyAnti-ZMPSTE24 antibodyAnti-FACE1 antibodyAnti-STE24 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of U-2 OS cells using [KO Validated] ERK2 Rabbit polyclonal antibody (STJ113009) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/92725/373210/STJ113009_1__36729.1713139394.jpg?c=1 "Immunofluorescence analysis of U-2 OS cells using [KO Validated] ERK2 Rabbit polyclonal antibody (STJ113009) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
