| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZCCHC8 (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZCCHC8 |
| Gene ID: |
55596 |
| Uniprot ID: |
ZCHC8_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ZCCHC8 (NP_060082.2). |
| Immunogen Sequence: |
MAAEVYFGDLELFEPFDHPE ESIPKPVHTRFKDDDGDEED ENGVGDAELRERLRQCEETI EQLRAENQELKRKLNILTRP SGILVNDTKLDGPILQILFM NNAISKQYHQEIEEFVSNLV KRFEEQQKNDVEKTSFNLLP QPSSIVLEEDHKVEESCAIK NNKEAFSVVGSVLYFTNFCL DKLGQPLLNENPQLSEGWEI PKYHQVFSHIVSLEGQEIQV KAKRPKPHCFNCGSEEHQM |
| Post Translational Modifications | Phosphorylation at Thr-492 by GSK3 is triggered in cells entering mitosis.this phosphorylation is greatly enhanced by nocodazole treatment, but reduced by lithium. |
| Function | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function. |
| Protein Name | Zinc Finger Cchc Domain-Containing Protein 8Tramp-Like Complex Rna-Binding Factor Zcchc8 |
| Cellular Localisation | NucleusNucleoplasmExcluded From Nucleolus |
| Alternative Antibody Names | Anti-Zinc Finger Cchc Domain-Containing Protein 8 antibodyAnti-Tramp-Like Complex Rna-Binding Factor Zcchc8 antibodyAnti-ZCCHC8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
