| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-VIPAS39 (1-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VIPAS39 |
| Gene ID: |
63894 |
| Uniprot ID: |
SPE39_HUMAN |
| Immunogen Region: |
1-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human VIPAS39 (NP_071350.2). |
| Immunogen Sequence: |
MNRTKGDEEEYWNSSKFKAF TFDDEDDELSQLKESKRAVN SLRDFVDDDDDDDLERVSWS GEPVGSISWSIRETAGNSGS THEGREQLKSRNSFSSYAQL PKPTSTYSLSSFFRGRTRPG SFQSLSDALSDTPAKSYAPE LGRPKGEYRDYSNDWSPSDT VRRLRKGKVCSLERFRSLQD KLQLLEEAVSMHDGNVITAV LIFLKRTLSKEILFRELEVR |
| Function | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes.the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin. |
| Protein Name | Spermatogenesis-Defective Protein 39 HomologHspe-39Vps33b-Interacting Protein In Apical-Basolateral Polarity RegulatorVps33b-Interacting Protein In Polarity And Apical Restriction |
| Cellular Localisation | CytoplasmCytoplasmic VesicleEarly EndosomeRecycling EndosomeLate EndosomeColocalizes In Clusters With Vps33b At Cytoplasmic Organelles |
| Alternative Antibody Names | Anti-Spermatogenesis-Defective Protein 39 Homolog antibodyAnti-Hspe-39 antibodyAnti-Vps33b-Interacting Protein In Apical-Basolateral Polarity Regulator antibodyAnti-Vps33b-Interacting Protein In Polarity And Apical Restriction antibodyAnti-VIPAS39 antibodyAnti-C14orf133 antibodyAnti-SPE39 antibodyAnti-VIPAR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
