Anti-TRIM8 antibody (STJA0007686)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TRIM8
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase TRIM8 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM8 |
| Gene ID | 81603 |
| Uniprot ID | TRIM8_HUMAN |
| Immunogen | Synthesized peptide derived from human TRIM8 |
| Specificity | This antibody detects endogenous levels of TRIM8 at Human, Mouse |
Additional Info
| Function | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim8Glioblastoma-Expressed Ring Finger ProteinRing Finger Protein 27Ring-Type E3 Ubiquitin Transferase Trim8Tripartite Motif-Containing Protein 8 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmNucleusNuclear BodyNucleo-Cytoplasmic Translocation Is Involved In Regulation Of Nf-Kappa-B |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim8 antibodyAnti-Glioblastoma-Expressed Ring Finger Protein antibodyAnti-Ring Finger Protein 27 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim8 antibodyAnti-Tripartite Motif-Containing Protein 8 antibodyAnti-TRIM8 antibodyAnti-GERP antibodyAnti-RNF27 antibody |
Information sourced from Uniprot.org