| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNKS2 (780-1050) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNKS2 |
| Gene ID: |
80351 |
| Uniprot ID: |
TNKS2_HUMAN |
| Immunogen Region: |
780-1050 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 780-1050 of human TNKS2 (NP_079511.1). |
| Immunogen Sequence: |
TPLDLVSADDVSALLTAAMP PSALPSCYKPQVLNGVRSPG ATADALSSGPSSPSSLSAAS SLDNLSGSFSELSSVVSSSG TEGASSLEKKEVPGVDFSIT QFVRNLGLEHLMDIFEREQI TLDVLVEMGHKELKEIGINA YGHRHKLIKGVERLISGQQG LNPYLTLNTSGSGTILIDLS PDDKEFQSVEEEMQSTVREH RDGGHAGGIFNRYNILKIQK VCNKKLWERYTHRRKEVSE |
| Tissue Specificity | Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain. |
| Post Translational Modifications | Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated.this leads to degradation. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer. |
| Function | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. |
| Protein Name | Poly Adp-Ribose Polymerase Tankyrase-2Adp-Ribosyltransferase Diphtheria Toxin-Like 6Artd6Poly Adp-Ribose Polymerase 5bProtein Poly-Adp-Ribosyltransferase Tankyrase-2Tnks-2Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2Tankyrase IiTankyrase-2Tank2Tankyrase-Like ProteinTankyrase-Related Protein |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4641257Reactome: R-HSA-5545619Reactome: R-HSA-5689880Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinNucleusChromosomeTelomereAssociated With The Golgi And With Juxtanuclear Slc2a4/Glut4-VesiclesAlso Found Around The Pericentriolar Matrix Of Mitotic CentromeresDuring InterphaseA Small Fraction Of Tnks2 Is Found In The NucleusAssociated With Trf1 |
| Alternative Antibody Names | Anti-Poly Adp-Ribose Polymerase Tankyrase-2 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 6 antibodyAnti-Artd6 antibodyAnti-Poly Adp-Ribose Polymerase 5b antibodyAnti-Protein Poly-Adp-Ribosyltransferase Tankyrase-2 antibodyAnti-Tnks-2 antibodyAnti-Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2 antibodyAnti-Tankyrase Ii antibodyAnti-Tankyrase-2 antibodyAnti-Tank2 antibodyAnti-Tankyrase-Like Protein antibodyAnti-Tankyrase-Related Protein antibodyAnti-TNKS2 antibodyAnti-PARP5B antibodyAnti-TANK2 antibodyAnti-TNKL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
