Anti-TLR2 antibody [TL2.1] {Biotin} (STJ16100491)

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STJ16100491-05

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Host: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-TLR2 is suitable for use in research applications.
Clonality: Monoclonal
Clone ID: TL2.1
Conjugation: Biotin
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: TLR2
Gene ID: 7097
Uniprot ID: TLR2_HUMAN
Post Translational Modifications Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
Function Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4. MAPK activation in response to bacterial peptidoglycan also occurs via this receptor. Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36).the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression. Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides. Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM.
Protein Name Toll-Like Receptor 2
Toll/Interleukin-1 Receptor-Like Protein 4
Cd Antigen Cd282
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-1461957
Reactome: R-HSA-166058
Reactome: R-HSA-168179
Reactome: R-HSA-168188
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5686938
Reactome: R-HSA-6798695
Reactome: R-HSA-9637628
Reactome: R-HSA-9705671
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cytoplasmic Vesicle
Phagosome Membrane
Membrane Raft
Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand
In Response To Diacylated Lipoproteins
Tlr2:Tlr6 Heterodimers Are Recruited In Lipid Rafts
This Recruitment Determines The Intracellular Targeting To The Golgi Apparatus
Triacylated Lipoproteins Induce The Same Mechanism For Tlr2:Tlr1 Heterodimers
Alternative Antibody Names Anti-Toll-Like Receptor 2 antibody
Anti-Toll/Interleukin-1 Receptor-Like Protein 4 antibody
Anti-Cd Antigen Cd282 antibody
Anti-TLR2 antibody
Anti-TIL4 antibody

Information sourced from Uniprot.org

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