| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-THAP1 (1-213) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
THAP1 |
| Gene ID: |
55145 |
| Uniprot ID: |
THAP1_HUMAN |
| Immunogen Region: |
1-213 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human THAP1 (NP_060575.1). |
| Immunogen Sequence: |
MVQSCSAYGCKNRYDKDKPV SFHKFPLTRPSLCKEWEAAV RRKNFKPTKYSSICSEHFTP DCFKRECNNKLLKENAVPTI FLCTEPHDKKEDLLEPQEQL PPPPLPPPVSQVDAAIGLLM PPLQTPVNLSVFCDHNYTVE DTMHQRKRIHQLEQQVEKLR KKLKTAQQRCRRQERQLEKL KEVVHFQKEKDDVSERGYVI LPNDYFEIVEVPA |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. |
| Function | DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-ATNTNNGTGGCAAGT-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. |
| Protein Name | Thap Domain-Containing Protein 1 |
| Cellular Localisation | NucleusNucleoplasmPml Body |
| Alternative Antibody Names | Anti-Thap Domain-Containing Protein 1 antibodyAnti-THAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
