Anti-SV2A nanobody [SAA2262] (STJN000706)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeAlpaca
General Information
| Short Description | Alpaca monoclonal nanobody anti-SV2A is suitable for use in Immunoprecipitation research applications. |
| Applications | IP |
| Host | Alpaca |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2262 |
| Isotype | Alpaca |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | Sv2a |
| Gene ID | 64051 |
| Uniprot ID | SV2A_MOUSE |
Additional Info
| Post Translational Modifications | Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. N-glycosylated. |
| Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA).the toxin probably binds via extracellular loop 4. (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD).BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E. (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E).the toxin probably binds via extracellular loop 4. It probably requires glycosylation of Asn-573. |
| Protein Name | Synaptic Vesicle Glycoprotein 2aSynaptic Vesicle Protein 2Synaptic Vesicle Protein 2aCalcium Regulator Sv2a |
| Database Links | |
| Cellular Localisation | PresynapseCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinEnriched In Chromaffin GranulesNot Present In Adrenal MicrosomesAssociated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The PancreasColocalizes With Atp2b1 At Photoreceptor Synaptic Terminals |
| Alternative Nanobody Names | Anti-Synaptic Vesicle Glycoprotein 2a nanobodyAnti-Synaptic Vesicle Protein 2 nanobodyAnti-Synaptic Vesicle Protein 2a nanobodyAnti-Calcium Regulator Sv2a nanobodyAnti-Sv2a nanobodyAnti-Kiaa0736 nanobodyAnti-Sv2 nanobody |
Information sourced from Uniprot.org