Anti-SLC25A39 antibody (170-250) (STJ117645)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC25A39 (170-250) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC25A39 |
| Gene ID | 51629 |
| Uniprot ID | S2539_HUMAN |
| Immunogen Region | 170-250 |
| Immunogen Sequence | LARLGTVTVISPLELMRTKL QAQHVSYRELGACVRTAVAQ GGWRSLWLGWGPTALRDVPF SALYWFNYELVKSWLNGFRP K |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 170-250 of human SLC25A39 (NP_001137252.1). |
Additional Info
| Tissue Specificity | Expressed in many tissues. Abundant in testis and kidney. |
| Post Translational Modifications | Cleaved and degraded by AFG3L2.degradation by AFG3L2 is regulated by the ability of SLC25A39 to bind iron-sulfur. In absence of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2. The presence of mitochondrial glutathione prevents iron-sulfur-binding to SLC25A39, promoting cleavage and degradation by AFG3L2. |
| Function | Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis. |
| Protein Name | Mitochondrial Glutathione Transporter Slc25a39Solute Carrier Family 25 Member 39 |
| Database Links | |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Glutathione Transporter Slc25a39 antibodyAnti-Solute Carrier Family 25 Member 39 antibodyAnti-SLC25A39 antibodyAnti-CGI-69 antibodyAnti-PRO2163 antibody |
Information sourced from Uniprot.org