| Background | This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca (2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Tissue Specificity | High levels in liver and low levels in kidney, pancreas, placenta, heart and brain. |
| Function | Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Protein Name | Calcium-Binding Mitochondrial Carrier Protein Aralar2CitrinMitochondrial Aspartate Glutamate Carrier 2Solute Carrier Family 25 Member 13 |
| Alternative Names | Anti-Calcium-Binding Mitochondrial Carrier Protein Aralar2 antibodyAnti-Citrin antibodyAnti-Mitochondrial Aspartate Glutamate Carrier 2 antibodyAnti-Solute Carrier Family 25 Member 13 antibodyAnti-SLC25A13 antibodyAnti-ARALAR2 antibody |
Information sourced from uniprot.org
