Anti-SENP1 antibody (1-50 aa) (STJ95601)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SENP1 at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Sentrin-specific protease 1 (1-50 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SENP1 |
| Gene ID | 29843 |
| Uniprot ID | SENP1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SENP1 at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | SENP1 Polyclonal Antibody detects endogenous levels of SENP1 protein. |
Additional Info
| Function | Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2. |
| Protein Name | Sentrin-Specific Protease 1Sentrin/Sumo-Specific Protease Senp1 |
| Database Links | Reactome: R-HSA-3065679Reactome: R-HSA-9035034 |
| Cellular Localisation | NucleusCytoplasmShuttles Between Cytoplasm And Nucleus |
| Alternative Antibody Names | Anti-Sentrin-Specific Protease 1 antibodyAnti-Sentrin/Sumo-Specific Protease Senp1 antibodyAnti-SENP1 antibody |
Information sourced from Uniprot.org