| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RIPK4 (240-520) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RIPK4Uniprot ID=RIPK4_HUMAN" |
| Immunogen Region: |
240-520 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-520 of human RIPK4 (NP_065690.2). |
| Immunogen Sequence: |
HRPELPPVCRARPRACSHLI RLMQRCWQGDPRVRPTFQEI TSETEDLCEKPDDEVKETAH DLDVKSPPEPRSEVVPARLK RASAPTFDNDYSLSELLSQL DSGVSQAVEGPEELSRSSSE SKLPSSGSGKRLSGVSSVDS AFSSRGSLSLSFEREPSTSD LGTTDVQKKKLVDAIVSGDT SKLMKILQPQDVDLALDSGA SLLHLAVEAGQEECAKWLLL NNANPNLSNRRGSTPLHMA |
| Tissue Specificity | Expressed in hair follicles and skin. |
| Post Translational Modifications | May be phosphorylated by MAP3K2 and MAP3K3. Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426. Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. |
| Function | Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. |
| Protein Name | Receptor-Interacting Serine/Threonine-Protein Kinase 4Ankyrin Repeat Domain-Containing Protein 3Pkc-Delta-Interacting Protein Kinase |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Interacting Serine/Threonine-Protein Kinase 4 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 3 antibodyAnti-Pkc-Delta-Interacting Protein Kinase antibodyAnti-RIPK4 antibodyAnti-ANKRD3 antibodyAnti-DIK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
