| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RIOK2 (253-552) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RIOK2 |
| Gene ID: |
55781 |
| Uniprot ID: |
RIOK2_HUMAN |
| Immunogen Region: |
253-552 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 253-552 of human RIOK2 (NP_060813.2). |
| Immunogen Sequence: |
TSHPNAEWYFDRDVKCIKDF FMKRFSYESELFPTFKDIRR EDTLDVEVSASGYTKEMQAD DELLHPLGPDDKNIETKEGS EFSFSDGEVAEKAEVYGSEN ESERNCLEESEGCYCRSSGD PEQIKEDSLSEESADARSFE MTEFNQALEEIKGQVVENNS VTEFSEEKNRTENYNRQDGQ RVQGGVPAGSDEYEDECPHL IALSSLNREFRPFRDEENVG AMNQYRTRTLSITSSGSAV |
| Post Translational Modifications | Autophosphorylated (in vitro). Phosphorylation at Ser-335, Ser-380, Ser-548 by PLK1 affects the timing of the metaphase-anaphase transition. |
| Function | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. |
| Protein Name | Serine/Threonine-Protein Kinase Rio2Rio Kinase 2 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmExported Out Of The Nucleus Via Its Nes In A Xpo1-Dependent Manner |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Rio2 antibodyAnti-Rio Kinase 2 antibodyAnti-RIOK2 antibodyAnti-RIO2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
