• Anti-REP1 antibody at 1:1000 dilution 50 ng of recombinant protein per lane rabbit polyclonal to goat IgG (HRP) at 1:10000 dilution.
  • Anti-REP1 antibody knockout validation with IPS cell line.
  • Anti-REP1 antibody knockout validation with ARPE-19 cell line.
  • Western blot of HIS-REP1 protein tag with Anti-REP1 antibody.
  • Anti-CHM antibody (617 to C-Term) (STJ140142)

Anti-CHM antibody (617 to C-Term) (STJ140142)

SKU:
STJ140142

£85.50 - £532.50
Current Stock:
Host: Goat
Applications: WB
Reactivity: Human/Rat/Mouse/Monkey/Canine
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Choroideremia (Rab escort protein 1) (617 to C-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 20% Glycerol and 0.05% Sodium Azide.
Purification: This antibody is epitope-affinity purified from goat antiserum.
Concentration: 4 mg/ml
Dilution Range: WB 1:500-1:2000
Storage Instruction: For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours.
Gene Symbol: CHM
Gene ID: 1121
Uniprot ID: RAE1_HUMAN
Immunogen Region: 617 to C-Term
Accession Number: ENSG00000188419
Specificity: Detects endogenous Rep1 and in transfected cells by Western blot.
Immunogen: Purified recombinant peptide derived from within residues 617 aa-stop at the C-terminus of human Rep1 produced in E. coli.
Function Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins.this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
Protein Name Rab Proteins Geranylgeranyltransferase Component A 1
Choroideremia Protein
Rab Escort Protein 1
Rep-1
Tcd Protein
Database Links Reactome: R-HSA-6803205
Reactome: R-HSA-8873719
Reactome: R-HSA-8876198
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Rab Proteins Geranylgeranyltransferase Component A 1 antibody
Anti-Choroideremia Protein antibody
Anti-Rab Escort Protein 1 antibody
Anti-Rep-1 antibody
Anti-Tcd Protein antibody
Anti-CHM antibody
Anti-REP1 antibody
Anti-TCD antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance