• Immunohistochemical stain on human prostate.

Anti-PSAP antibody [IHC655] (STJ160017)

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STJ160017

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Host: Mouse
Applications: IHC-p
Reactivity: Human
Short Description: Mouse monoclonal anti-PSAP antibody is suitable for use in Immunohistochemistry.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: IHC655
Conjugation: Unconjugated
Formulation: Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Storage Instruction: Store at 2-8°C. Do not freeze.
Dilution Range: 1:100-1:200
Uniprot ID: SAP_HUMAN
Gene ID: 5660
Gene Symbol: PSAP
Immunogen: Human PSAP protein.
Accession Number: P07602
Post Translational Modifications The lysosomal precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins. N-linked glycans show a high degree of microheterogeneity. The one residue extended Saposin-B-Val is only found in 5% of the chains.
Function Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator. Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
Protein Name Prosaposin
Proactivator Polypeptide Cleaved Into - Saposin-A
Protein A - Saposin-B-Val - Saposin-B
Cerebroside Sulfate Activator
Csact
Dispersin
Sphingolipid Activator Protein 1
Sap-1
Sulfatide/Gm1 Activator - Saposin-C
A1 Activator
Co-Beta-Glucosidase
Glucosylceramidase Activator
Sphingolipid Activator Protein 2
Sap-2 - Saposin-D
Component C
Protein C
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1660662
Reactome: R-HSA-375276
Reactome: R-HSA-418594
Reactome: R-HSA-6798695
Cellular Localisation Lysosome
Prosaposin: Secreted
Secreted As A Fully Glycosylated 70 Kda Protein Composed Of Complex Glycans
Alternative Antibody Names Anti-Prosaposin antibody
Anti-Proactivator Polypeptide Cleaved Into - Saposin-A antibody
Anti-Protein A - Saposin-B-Val - Saposin-B antibody
Anti-Cerebroside Sulfate Activator antibody
Anti-Csact antibody
Anti-Dispersin antibody
Anti-Sphingolipid Activator Protein 1 antibody
Anti-Sap-1 antibody
Anti-Sulfatide/Gm1 Activator - Saposin-C antibody
Anti-A1 Activator antibody
Anti-Co-Beta-Glucosidase antibody
Anti-Glucosylceramidase Activator antibody
Anti-Sphingolipid Activator Protein 2 antibody
Anti-Sap-2 - Saposin-D antibody
Anti-Component C antibody
Anti-Protein C antibody
Anti-PSAP antibody
Anti-GLBA antibody
Anti-SAP1 antibody

Information sourced from Uniprot.org

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