||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-PPAR gamma is suitable for use in Western Blot and Immunohistochemistry.
||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
||WB 1:500-1:1000IHC 1:50-1:100
||Store at-20°C. Avoid freeze/thaw cycles.
||A synthetic peptide corresponding to a sequence within amino acids 70-170 of human PPAR gamma (NP_056953.2).
| Tissue Specificity || Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
| Post Translational Modifications || O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes. Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity. |
| Function || Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. |
| Protein Name || Peroxisome Proliferator-Activated Receptor GammaPpar-GammaNuclear Receptor Subfamily 1 Group C Member 3 |
| Database Links || Reactome: R-HSA-1989781Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-4090294Reactome: R-HSA-8943724Reactome: R-HSA-9022707 |
| Cellular Localisation || NucleusCytoplasmRedistributed From The Nucleus To The Cytosol Through A Map2k1/Mek1-Dependent MannerNoct Enhances Its Nuclear Translocation |
| Alternative Antibody Names || Anti-Peroxisome Proliferator-Activated Receptor Gamma antibodyAnti-Ppar-Gamma antibodyAnti-Nuclear Receptor Subfamily 1 Group C Member 3 antibodyAnti-PPARG antibodyAnti-NR1C3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance