Anti-PP2A-gamma antibody (390-439) (STJ505956)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 390-439 on human Serine/Threonine-Protein Phosphatase 2A B56 Gamma1 subunit.
General Information
| Short Description | Rabbit polyclonal antibody anti-PP2A-gamma (390-439) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.5 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP2R5C |
| Gene ID | 5527 |
| Uniprot ID | 2A5G_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 390-439 on human Serine/Threonine-Protein Phosphatase 2A B56 Gamma1 subunit. |
| Immunogen Region | 390-439 |
Additional Info
| Post Translational Modifications | Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C. |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma IsoformPp2a B Subunit Isoform B'-GammaPp2a B Subunit Isoform B56-GammaPp2a B Subunit Isoform Pr61-GammaPp2a B Subunit Isoform R5-GammaRenal Carcinoma Antigen Ny-Ren-29 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6804757Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromere |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform antibodyAnti-Pp2a B Subunit Isoform B'-Gamma antibodyAnti-Pp2a B Subunit Isoform B56-Gamma antibodyAnti-Pp2a B Subunit Isoform Pr61-Gamma antibodyAnti-Pp2a B Subunit Isoform R5-Gamma antibodyAnti-Renal Carcinoma Antigen Ny-Ren-29 antibodyAnti-PPP2R5C antibodyAnti-KIAA0044 antibody |
Information sourced from Uniprot.org