Anti-PLCB2 antibody (1-199) (STJ110440)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PLCB2 (1-199) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLCB2 |
| Gene ID | 5330 |
| Uniprot ID | PLCB2_HUMAN |
| Immunogen Region | 1-199 |
| Immunogen Sequence | MSLLNPVLLPPKVKAYLSQG ERFIKWDDETTVASPVILRV DPKGYYLYWTYQSKEMEFLD ITSIRDTRFGKFAKMPKSQK LRDVFNMDFPDNSFLLKTLT VVSGPDMVDLTFHNFVSYKE NVGKAWAEDVLALVKHPLTA NASRSTFLDKILVKLKMQLN SEGKIPVKNFFQMFPADRKR VEAALSACHLPKGKNDAIN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human PLCB2 (NP_004564.2). |
Additional Info
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-2Phosphoinositide Phospholipase C-Beta-2Phospholipase C-Beta-2Plc-Beta-2 |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-1855204Reactome: R-HSA-399997Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-418217Reactome: R-HSA-434316Reactome: R-HSA-500657Reactome: R-HSA-9717207 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-2 antibodyAnti-Phosphoinositide Phospholipase C-Beta-2 antibodyAnti-Phospholipase C-Beta-2 antibodyAnti-Plc-Beta-2 antibodyAnti-PLCB2 antibody |
Information sourced from Uniprot.org