Anti-PIGR nanobody [SAA1311] (STJN000084)

Anti-PIGR nanobody [SAA1311] (STJN000084)

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STJN000084
€473.13 - €2,040.63
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Polymeric Immunoglobulin Receptor is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1311
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: PIGR
Gene ID: 5284
Uniprot ID: PIGR_HUMAN
Function Polymeric immunoglobulin receptor: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Secretory component: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
Protein Name Polymeric Immunoglobulin Receptor
Pigr
Poly-Ig Receptor
Hepatocellular Carcinoma-Associated Protein Tb6 Cleaved Into - Secretory Component
Database Links Reactome: R-HSA-6798695
Cellular Localisation Polymeric Immunoglobulin Receptor: Cell Membrane
Single-Pass Type I Membrane Protein
Secretory Component: Secreted
Alternative Nanobody Names Anti-Polymeric Immunoglobulin Receptor nanobody
Anti-Pigr nanobody
Anti-Poly-Ig Receptor nanobody
Anti-Hepatocellular Carcinoma-Associated Protein Tb6 Cleaved Into - Secretory Component nanobody
Anti-PIGR nanobody

Information sourced from Uniprot.org

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